Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, leading to vasodilation and reduced peripheral vascular resistance. By effectively lowering blood pressure, it mitigates a primary risk factor for cardiovascular disease, stroke, and kidney disease, thereby supporting long-term cardiovascular health and potentially extending healthspan.
Verdict
Effective for hypertension; critical for cardiovascular healthspan.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$5 - $30
Protocol
- Standard dosing for hypertension typically ranges from 2.5 mg to 10 mg once daily, titrated to achieve optimal blood pressure control.
Flags
- Common side effects include peripheral edema, headache, flushing, and fatigue.
- Caution with grapefruit juice, which can increase amlodipine levels.
- Potential for drug interactions with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir).
- Not recommended for individuals with severe aortic stenosis or cardiogenic shock.
- Requires regular blood pressure monitoring and medical supervision.