Meta Information

ID:amlodipine

Name:Amlodipine

Schema Version:1.5

Alternate Names

• Norvasc
• Katerzia
• Amvaz

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

30

Cost Type:

monthly

Description:

Low-cost generic, often covered by insurance for hypertension.

Summary

Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, leading to vasodilation and reduced peripheral vascular resistance. By effectively lowering blood pressure, it mitigates a primary risk factor for cardiovascular disease, stroke, and kidney disease, thereby supporting long-term cardiovascular health and potentially extending healthspan.

Purpose

Manages hypertension to reduce cardiovascular risk and support healthspan.

Card Summary

Amlodipine is a calcium channel blocker used to lower blood pressure, reducing cardiovascular disease risk.

Drug Class

Calcium Channel Blockers (Dihydropyridine)

Drugs In Class

Empty Array

Impact

Score:

7.5

Justification:

Robustly lowers blood pressure, significantly reducing cardiovascular disease risk.

Evidence

Grade:

A

Score:

9

Justification:

Extensive human RCTs and meta-analyses confirm efficacy for hypertension.

Safety

Score:

5

Justification:

Common side effects like edema, but generally well-tolerated with supervision.

Flags

• Common side effects include peripheral edema, headache, flushing, and fatigue.
• Caution with grapefruit juice, which can increase amlodipine levels.
• Potential for drug interactions with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir).
• Not recommended for individuals with severe aortic stenosis or cardiogenic shock.
• Requires regular blood pressure monitoring and medical supervision.

Verdict

Effective for hypertension; critical for cardiovascular healthspan.

Model

Gemini 3 Flash

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Amlodipine is a dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, leading to vasodilation and reduced peripheral vascular resistance. By effectively lowering blood pressure,...

Typical Protocol

• Standard dosing for hypertension typically ranges from 2.5 mg to 10 mg once daily, titrated to achieve optimal blood pressure control.