Alpha-lipoic acid is a naturally occurring mitochondrial coenzyme and potent antioxidant found in every cell. It directly neutralizes free radicals and helps regenerate other key antioxidants like glutathione, vitamin C, and vitamin E. Its relevance to healthspan is based on its potential to combat oxidative stress and support cellular energy production, two processes that degrade with age.
Verdict
A plausible but unproven antioxidant for general healthspan benefits.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $30
Protocol
- Daily oral supplementation of 300-600 mg of a mixed isomer (R/S-ALA) form is common.
- For the more bioavailable R-ALA form, daily oral doses are typically 100-300 mg.
Flags
- May lower blood sugar levels; caution advised for diabetics or those on glucose-lowering medication.
- High doses may interfere with thyroid hormone function and conversion.
- Can cause stomach upset or skin rashes in sensitive individuals.