Meta Information
ID:alpha-lipoic-acid
Name:Alpha-Lipoic Acid
Schema Version:1.5
Alternate Names
- ALA
- Thioctic acid
Active Compound
alpha-lipoic acid
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:rx_drug
Indication
Focus:
healthspan
Description:
Targeted to mitigate age-related increases in oxidative stress and support mitochondrial function, particularly in the context of glucose metabolism.
Typical Protocol
- Daily oral supplementation of 300-600 mg of a mixed isomer (R/S-ALA) form is common.
- For the more bioavailable R-ALA form, daily oral doses are typically 100-300 mg.
Expected Cost Mean
Low Cost:
10
High Cost:
30
Cost Type:
monthly
Description:
Cost for daily over-the-counter oral supplement; not covered by insurance.
Summary
Alpha-lipoic acid is a naturally occurring mitochondrial coenzyme and potent antioxidant found in every cell. It directly neutralizes free radicals and helps regenerate other key antioxidants like glutathione, vitamin C, and vitamin E. Its relevance to healthspan is based on its potential to combat oxidative stress and support cellular energy production, two processes that degrade with age.
Purpose
Mitochondrial coenzyme and antioxidant supporting cellular energy and defense.
Card Summary
A mitochondrial antioxidant that supports cellular energy production.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
Plausible mechanism but lacks robust human data for general healthspan extension.
Evidence
Grade:
B
Score:
5
Justification:
Human trials exist for disease, but evidence for healthspan in healthy individuals is limited.
Safety
Score:
3
Justification:
Generally recognized as safe at typical doses, but can lower blood sugar.
Flags
- May lower blood sugar levels; caution advised for diabetics or those on glucose-lowering medication.
- High doses may interfere with thyroid hormone function and conversion.
- Can cause stomach upset or skin rashes in sensitive individuals.
Verdict
A plausible but unproven antioxidant for general healthspan benefits.
Created
2026-05-05T21:56:36.988414Z
Ai Model
Gemini 2.5 Pro (High)