Alpha-GPC is a highly bioavailable choline compound that serves as a precursor to the neurotransmitter acetylcholine. It is primarily used to support cognitive functions like memory and learning. Its relevance to healthspan is focused on maintaining neurological health and potentially mitigating age-related cognitive decline, though its impact on overall lifespan is not established.
Verdict
Cognitive benefits may be outweighed by potential long-term cardiovascular risks.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Take 300-600 mg daily, often before mentally demanding tasks or exercise.
Flags
- A 2021 observational study associated long-term use with a significantly increased risk of stroke.
- May increase TMAO levels, a metabolite linked to cardiovascular disease.
- Can cause side effects like headache, heartburn, insomnia, or dizziness at higher doses.