Meta Information
ID:alpha-gpc
Name:Alpha-GPC
Schema Version:1.5
Alternate Names
- L-Alpha glycerylphosphorylcholine
- Choline alfoscerate
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
15
High Cost:
40
Cost Type:
monthly
Description:
Cost for a typical 30-day supply of capsules or powder.
Summary
Alpha-GPC is a highly bioavailable choline compound that serves as a precursor to the neurotransmitter acetylcholine. It is primarily used to support cognitive functions like memory and learning. Its relevance to healthspan is focused on maintaining neurological health and potentially mitigating age-related cognitive decline, though its impact on overall lifespan is not established.
Purpose
A bioavailable choline source to support cognitive function and neurotransmission.
Drug Class
cholinergic
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
Primarily supports cognitive function with limited evidence for systemic healthspan extension.
Evidence
Grade:
B
Score:
5.5
Justification:
Human trials exist for cognitive decline and performance, but not for longevity.
Safety
Score:
4.2
Justification:
Generally well-tolerated but an observational study linked it to increased stroke risk.
Flags
- A 2021 observational study associated long-term use with a significantly increased risk of stroke.
- May increase TMAO levels, a metabolite linked to cardiovascular disease.
- Can cause side effects like headache, heartburn, insomnia, or dizziness at higher doses.
Verdict
Cognitive benefits may be outweighed by potential long-term cardiovascular risks.
Created
2026-04-27T00:48:30.498208Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Alpha-GPC is a highly bioavailable choline compound that serves as a precursor to the neurotransmitter acetylcholine. It is primarily used to support cognitive functions like memory and learning. Its ...
Typical Protocol
- Take 300-600 mg daily, often before mentally demanding tasks or exercise.