Meta Information
ID:vitamin-d
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:28:20.417648Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/weight-bearing-exercise
Target name:
Weight-Bearing Exercise
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Exercise signals bones to get stronger, and Vitamin D provides the necessary calcium to do so.
Actionable advice:
Combine for optimal bone health.
Target id:
/intervention/denosumab
Target name:
Denosumab
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Adequate Vitamin D is required to prevent severe low blood calcium, a side effect of this drug.
Actionable advice:
Ensure Vitamin D and calcium are sufficient.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Adequate Vitamin D is necessary for this osteoporosis medication class to work effectively and safely.
Actionable advice:
Ensure Vitamin D and calcium are sufficient.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
High Vitamin D can raise calcium levels, increasing the risk of serious digoxin heart toxicity.
Actionable advice:
Monitor calcium and digoxin levels closely.
Target id:
/intervention/calcium-akg
Target name:
Calcium Alpha-Ketoglutarate
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin D significantly enhances the absorption of calcium, making them work better together for bone health.
Actionable advice:
Often recommended to be taken together.
Target id:
/intervention/calcium-citrate
Target name:
Calcium Citrate
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin D significantly enhances the absorption of calcium, making them work better together for bone health.
Actionable advice:
Often recommended to be taken together.
Target id:
/intervention/teriparatide
Target name:
Teriparatide
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Both substances increase blood calcium levels, raising the risk of hypercalcemia (too much calcium) when combined.
Actionable advice:
Monitor blood calcium levels regularly.
Target id:
/intervention/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These cholesterol drugs can bind to Vitamin D in the gut, significantly reducing its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/vitamin-k2
Target name:
Vitamin K2
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin K2 helps direct the calcium absorbed by Vitamin D into bones, away from soft tissues.
Actionable advice:
Consider co-supplementation for bone/heart health.
Target id:
/intervention/menopausal-hrt
Target name:
Menopausal HRT
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Both hormone therapy and Vitamin D help maintain bone density, providing a combined benefit for bone health.
Actionable advice:
Ensure adequate Vitamin D during HRT.
Target id:
/intervention/strontium
Target name:
Strontium
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Strontium and calcium (whose absorption is boosted by Vitamin D) compete for absorption in the gut.
Actionable advice:
Separate doses by at least 2-3 hours.
Target id:
/intervention/saint-johns-wort
Target name:
Saint John's Wort
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
This herb can speed up the breakdown of Vitamin D in the body, potentially lowering its levels.
Actionable advice:
Monitor Vitamin D levels with long-term use.
Target id:
/intervention/ipriflavone
Target name:
Ipriflavone
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
This supplement may work with Vitamin D and calcium to improve bone density and prevent bone loss.
Actionable advice:
Often used in combination for bone health.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Magnesium is essential for activating Vitamin D, so adequate levels are needed for it to work properly.
Actionable advice:
Ensure adequate magnesium intake for efficacy.
Target id:
/intervention/boron
Target name:
Boron
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Boron may help increase Vitamin D levels in the body and supports its role in bone health.
Actionable advice:
May enhance Vitamin D status.
Target id:
/intervention/sglt2-inhibitors
Target name:
SGLT2 Inhibitors
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
This drug class may increase fracture risk; adequate Vitamin D is crucial to support bone health.
Actionable advice:
Ensure adequate Vitamin D and calcium intake.
Target id:
/intervention/high-fiber-diet
Target name:
High-Fiber Diet
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Very high fiber intake, especially from phytates, can slightly reduce absorption of Vitamin D and calcium.
Actionable advice:
Separate from high-phytate meals if concerned.
Target id:
/intervention/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Long-term use may reduce calcium absorption, which is crucial for Vitamin D's function in bone health.
Actionable advice:
Ensure adequate calcium intake and monitoring.
Target id:
/intervention/statins
Target name:
Statins
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Statins may slightly interfere with the body's ability to synthesize Vitamin D from cholesterol precursors.
Actionable advice:
Monitor Vitamin D levels if concerned.