Meta Information

ID:vitamin-b6

Name:Vitamin B6

Schema Version:1.5

Title

Vitamin B6

Alternate Names

• Pyridoxine
• Pyridoxal 5'-Phosphate
• P-5-P

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

15

Cost Type:

monthly

Description:

Widely available and inexpensive over-the-counter supplement.

Summary

Vitamin B6 is an essential water-soluble vitamin that acts as a coenzyme in over 100 metabolic reactions, primarily related to amino acid metabolism. For healthspan, its most critical role is in the pathway that converts homocysteine to cysteine, helping to keep homocysteine levels low. Elevated homocysteine is a well-established risk factor for cardiovascular disease, stroke, and cognitive decline, making B6 a key component of metabolic and neurological maintenance.

Purpose

Essential coenzyme for metabolism, neurotransmitter synthesis, and homocysteine regulation.

Card Summary

An essential coenzyme involved in amino acid metabolism, neurotransmitter synthesis, and regulating homocysteine levels, a key marker for cardiovascular and cognitive health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Essential for foundational metabolic health, but supra-physiological doses lack strong longevity evidence.

Evidence

Grade:

B

Score:

7

Justification:

Strong evidence for its essential role; moderate observational data for longevity benefits.

Safety

Score:

3.8

Justification:

Generally safe, but high chronic doses can cause irreversible nerve damage (peripheral neuropathy).

Flags

• Chronic high doses (>100 mg/day) are associated with a significant risk of peripheral neuropathy.
• May interfere with the efficacy of certain drugs, including levodopa, phenobarbital, and phenytoin.
• The pyridoxal 5'-phosphate (P-5-P) form is often preferred for better bioavailability.
• Deficiency is rare but can be a concern with certain medical conditions or diets.

Verdict

Ensure dietary sufficiency; supplement cautiously, avoiding chronic high doses.

Created

2026-04-24T00:17:23.978295Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Vitamin B6 is an essential water-soluble vitamin that acts as a coenzyme in over 100 metabolic reactions, primarily related to amino acid metabolism. For healthspan, its most critical role is in the p...

Typical Protocol

• Daily intake of 25-50 mg, often as the active form Pyridoxal-5-Phosphate (P-5-P).
• Ensure intake meets the RDA of 1.3-1.7 mg/day through diet or supplementation.