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Type II Collagen

Undenatured Type II Collagen, UC-II, Hydrolyzed Type II Collagen

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Meta Information

ID:type-ii-collagen
Name:Type II Collagen
Schema Version:1.5

Alternate Names

  • Undenatured Type II Collagen
  • UC-II
  • Hydrolyzed Type II Collagen

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
50
Cost Type:
monthly
Description:
Monthly cost for daily supplementation, not typically covered by insurance.

Summary

Type II collagen is the primary structural protein in cartilage, crucial for joint flexibility and strength. Supplementation, particularly with the undenatured form (UC-II), is thought to work via oral tolerance, a process where the immune system is trained to recognize it as harmless, thereby reducing inflammatory attacks on the body's own joint cartilage. For healthspan, this translates to preserving mobility, reducing age-related joint pain, and maintaining an active lifestyle.

Purpose

Supports joint cartilage integrity, mobility, and reduces joint discomfort.

Card Summary

A key cartilage protein that may reduce joint inflammation and preserve mobility.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Targeted benefit for joint health and mobility, not a systemic longevity driver.

Evidence

Grade:
A
Score:
8.5
Justification:
Multiple human RCTs and meta-analyses confirm benefits for joint pain and function.

Safety

Score:
2.5
Justification:
Generally Recognized As Safe (GRAS) with a very low incidence of side effects.

Flags

  • Derived from animal sources (typically chicken); not suitable for vegans.
  • Potential for allergic reaction in individuals with chicken or egg allergies.
  • Undenatured (UC-II) and hydrolyzed forms have different mechanisms and dosages.

Verdict

A well-evidenced, safe supplement for supporting joint health and mobility.

Created

2026-04-26T18:16:23.767359Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Type II collagen is the primary structural protein in cartilage, crucial for joint flexibility and strength. Supplementation, particularly with the undenatured form (UC-II), is thought to work via ora...

Typical Protocol

  • Take 40mg of undenatured type II collagen (UC-II) once daily, often on an empty stomach.
  • Take 2-10 grams of hydrolyzed type II collagen daily, typically mixed into a beverage.