The TRIIM protocol combines several agents to regenerate the thymus gland, a key organ for adaptive immunity that shrinks with age. By using growth hormone to stimulate thymic tissue and metformin/DHEA to mitigate GH's pro-aging metabolic effects, it aims to reverse immunosenescence. A small pilot study showed a significant reversal of epigenetic age, suggesting a potential systemic rejuvenation effect.
Verdict
Highly experimental protocol with profound potential but very limited human data.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
High
EVIDENCE GRADE
B
MONTHLY COST
$1100 - $3100
Protocol
- A one-year protocol combining weekly injections of recombinant human growth hormone (rhGH) with daily oral DHEA, Metformin, Zinc, and Vitamin D3 under strict medical supervision.
Flags
- Requires a prescription and close monitoring by a qualified physician.
- Human Growth Hormone (hGH) is a controlled substance in many regions.
- The foundational study was very small and lacked a placebo control group.
- Long-term safety and efficacy for longevity purposes are unknown.
- Potential for significant side effects from individual components (e.g., hGH, Metformin).