Trehalose is a naturally occurring disaccharide composed of two glucose molecules. Unlike table sugar, it is metabolized slowly and is proposed to promote healthspan by inducing autophagy, the body's cellular recycling process, which typically declines with age. It may also act as a chemical chaperone, helping proteins maintain their correct shape and preventing the formation of toxic aggregates implicated in age-related diseases.
Verdict
Highly experimental autophagy inducer with limited human evidence for healthspan.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$5 - $15
Protocol
- Typical doses range from 1 to 2 teaspoons (approximately 4-8 grams) dissolved in liquid daily.
- Due to potential gastrointestinal side effects, starting with a lower dose is often recommended.
Flags
- It is a sugar and contains calories (4 kcal/gram), which must be accounted for.
- Commonly causes gastrointestinal side effects like gas, bloating, and diarrhea.
- Individuals with a genetic trehalase deficiency cannot digest it, leading to severe GI symptoms.
- May modestly increase blood glucose levels, requiring caution for individuals with metabolic syndrome or diabetes.