Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) primarily used as an antidepressant. For healthspan, it is widely used off-label at low doses as a non-addictive hypnotic to improve sleep architecture, particularly increasing slow-wave (deep) sleep. High-quality sleep is foundational for cellular repair, glymphatic clearance in the brain, and hormonal regulation, making it a key leverage point for longevity.
Verdict
Effective sleep aid, but requires prescription and awareness of side effects.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$5 - $20
Protocol
- 25-100 mg taken 30-60 minutes before bedtime for sleep quality improvement.
Flags
- Risk of serotonin syndrome when combined with other serotonergic agents (e.g., SSRIs, MAOIs).
- May cause significant next-day grogginess or 'hangover' effect.
- Rare but serious risk of priapism (prolonged erection) requiring immediate medical attention.
- Potential for orthostatic hypotension (dizziness upon standing), increasing fall risk.
- Use with caution in individuals with pre-existing cardiac conditions due to arrhythmia risk.