Niacinamide is a form of vitamin B3 that, when applied topically, acts as a precursor to NAD+, a critical coenzyme in cellular energy metabolism and DNA repair. It improves skin barrier function, reduces inflammation, and may mitigate UV-induced cellular damage, thereby addressing key drivers of skin aging.
Verdict
A safe, evidence-based topical for improving skin health and appearance.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Very Low
EVIDENCE GRADE
A
MONTHLY COST
$10 - $40
Protocol
- Apply a 2-10% concentration formulation to the face once or twice daily.
Flags
- High concentrations (>10%) may cause skin irritation or flushing.
- Efficacy is formulation-dependent; choose reputable brands.