Meta Information

ID:tirzepatide

Name:Tirzepatide

Schema Version:1.5

Title

Tirzepatide

Alternate Names

• Mounjaro
• Zepbound

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

1000

High Cost:

1300

Cost Type:

monthly

Description:

Monthly cost for four weekly injections without insurance coverage.

Summary

Tirzepatide is a dual GIP and GLP-1 receptor agonist that promotes insulin sensitivity, significant weight loss, and reduces inflammation. Its primary healthspan relevance stems from its profound impact on metabolic health, a cornerstone of longevity, by mimicking the effects of powerful satiety and glucose-regulating hormones.

Purpose

Dual-agonist drug for profound metabolic health improvement and weight management.

Card Summary

A powerful dual-agonist injection for major improvements in metabolic health and weight.

Drug Class

glp-1-receptor-agonists

Drugs In Class

Empty Array

Impact

Score:

8.2

Justification:

Profound, systemic improvements in metabolic health, a primary driver of aging.

Evidence

Grade:

A

Score:

9.5

Justification:

Multiple large-scale human RCTs show profound metabolic and weight loss benefits.

Safety

Score:

5.8

Justification:

Regulated drug with common GI side effects; requires medical supervision.

Flags

• Common side effects include nausea, diarrhea, and constipation, especially during dose escalation.
• Risk of muscle mass loss alongside fat loss; resistance training is crucial.
• Boxed warning for risk of thyroid C-cell tumors based on rodent studies.
• May reduce the efficacy of oral contraceptives due to delayed gastric emptying.
• Requires a prescription and ongoing medical supervision.

Verdict

A powerful tool for metabolic health, but requires medical guidance.

Created

2026-04-24T00:14:45.307087Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

subcutaneous_injection

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Tirzepatide is a dual GIP and GLP-1 receptor agonist that promotes insulin sensitivity, significant weight loss, and reduces inflammation. Its primary healthspan relevance stems from its profound impa...

Typical Protocol

• Start at 2.5 mg weekly via subcutaneous injection, titrating up slowly based on tolerance and goals.