Time-Restricted Eating (16:8) - Healthspan Clinical Wiki

Meta Information

ID:time-restricted-eating

Name:Time-Restricted Eating (16:8)

Schema Version:1.5

Title

Time-Restricted Eating (16:8)

Alternate Names

TRE
16:8 Intermittent Fasting
Leangains Protocol

Intervention Type

dietary_practice

Expected Cost Mean

Low Cost:

High Cost:

Cost Type:

monthly

Description:

No direct cost; potential savings on food expenses.

Summary

Time-restricted eating aligns feeding patterns with circadian rhythms, which can improve metabolic health. The daily 16-hour fast promotes metabolic switching from glucose to fat-based energy and may activate cellular cleanup processes (autophagy), which are linked to enhanced cellular resilience and reduced inflammation.

Purpose

Aligns circadian rhythms and promotes metabolic flexibility for healthspan.

Card Summary

A daily 16-hour fast to align circadian rhythms and improve metabolic health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.2

Justification:

Strongly influences metabolic health, insulin sensitivity, and circadian rhythm alignment.

Evidence

Grade:

Score:

7.5

Justification:

Multiple human trials show metabolic benefits; long-term longevity data is still developing.

Safety

Score:

1.5

Justification:

Generally very safe for healthy adults; requires caution in specific populations.

Flags

May be contraindicated for individuals with a history of eating disorders.
Consult a physician if you are pregnant, breastfeeding, or have diabetes.
Initial adjustment period may include hunger, irritability, or headaches.
Maintaining nutrient adequacy within the compressed eating window is crucial.

Verdict

A powerful, low-cost tool for improving metabolic health.

Created

2026-04-24T00:14:31.414903Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

systemic

Indication

Focus:

healthspan

Description:

Typical Protocol

Consume all daily calories within a consistent 8-hour window, followed by a 16-hour fast.