Meta Information

ID:therapeutic-plasma-exchange

Name:Therapeutic Plasma Exchange (TPE)

Schema Version:1.5

Title

Therapeutic Plasma Exchange (TPE)

Alternate Names

• Plasmapheresis
• Plasma Exchange
• Plasma Dilution

Intervention Type

procedure

Expected Cost Mean

Low Cost:

8000

High Cost:

25000

Cost Type:

one time

Description:

Cost per course of multiple sessions, often repeated annually.

Summary

Therapeutic Plasma Exchange is a medical procedure that removes a patient's blood plasma and replaces it with a substitute fluid, typically albumin and saline. The primary healthspan hypothesis is that this process dilutes and removes accumulated pro-aging factors from the bloodstream, such as inflammatory cytokines, metabolic waste, and circulating pro-fibrotic proteins. By 'cleaning' the systemic environment, TPE may help rejuvenate tissues and restore more youthful cellular function, a concept demonstrated in animal models.

Purpose

Dilutes pro-aging factors in blood to promote systemic rejuvenation.

Card Summary

A procedure that replaces blood plasma to dilute accumulated pro-aging factors, potentially reversing some age-related dysfunction.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.8

Justification:

Highly promising in animal models but lacks robust human longevity data.

Evidence

Grade:

C

Score:

3.5

Justification:

Strong animal data; human trials for longevity are preliminary and small.

Safety

Score:

7.2

Justification:

Invasive medical procedure with risks of infection, clotting, and hemodynamic instability.

Flags

• Requires strict medical supervision in a clinical setting.
• Risks include infection, allergic reactions to albumin, and citrate toxicity.
• Can cause significant shifts in blood pressure and fluid balance during the procedure.
• Long-term effects of repeated treatments in healthy individuals are unknown.
• Cost is a significant barrier to access.

Verdict

A high-potential but experimental and costly procedure lacking human longevity data.

Created

2026-04-24T00:14:02.293114Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Therapeutic Plasma Exchange is a medical procedure that removes a patient's blood plasma and replaces it with a substitute fluid, typically albumin and saline. The primary healthspan hypothesis is tha...

Typical Protocol

• A series of 3-6 exchanges over several weeks, often repeated annually or semi-annually.