DHEA is a precursor hormone that declines significantly with age. Supplementation aims to restore youthful levels, which may influence downstream hormones like testosterone and estrogen. The sustained-release formulation is designed to mimic the body's natural diurnal rhythm, avoiding the sharp spikes and rapid clearance of immediate-release versions, potentially leading to more stable physiological effects and better tolerance.
Verdict
Consider for documented deficiency under medical guidance; evidence for general healthspan is weak.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Typical doses range from 10-50 mg taken once daily, usually in the morning to mimic natural circadian rhythms.
- The sustained-release formulation is designed to provide a more stable, physiological release profile over 24 hours.
- Blood levels of DHEA-S and downstream hormones (testosterone, estradiol) should be monitored to guide dosing.
Flags
- Can increase estrogen and testosterone levels; not recommended for individuals with hormone-sensitive cancers.
- Potential side effects include acne, hair loss, mood changes, and unwanted hair growth.
- Banned by many sports organizations (WADA) as a performance-enhancing anabolic agent.
- Regular blood testing of DHEA-S, testosterone, and estradiol is recommended to guide dosing.
- Legal status varies globally; it is a controlled substance in many countries outside the US.