Meta Information

ID:sirt6-gene-therapy

Name:SIRT6 Gene Therapy

Schema Version:1.5

Title

SIRT6 Gene Therapy

Alternate Names

• SIRT6 Overexpression Therapy

Intervention Type

procedure

Expected Cost Mean

Low Cost:

1000000

High Cost:

4000000

Cost Type:

one time

Description:

Extremely high one-time cost reflecting its current experimental gene therapy status.

Summary

SIRT6 is a sirtuin protein crucial for DNA repair, genomic stability, and metabolic regulation. Gene therapy aims to increase SIRT6 levels, which has been shown in animal models to extend lifespan and healthspan by bolstering these core cellular maintenance processes that degrade with age. This intervention directly targets multiple hallmarks of aging, representing a potentially foundational approach to longevity.

Purpose

Enhances DNA repair and genomic stability to extend healthspan.

Card Summary

A gene therapy designed to increase SIRT6 protein levels, enhancing DNA repair, genomic stability, and metabolic function to combat multiple hallmarks of aging.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

9.5

Justification:

Theoretically targets multiple core hallmarks of aging, including genomic instability and DNA repair.

Evidence

Grade:

C

Score:

3.5

Justification:

Compelling lifespan extension in mice, but currently zero human clinical trial data exists.

Safety

Score:

9

Justification:

Involves viral vectors with risks of immunogenicity, oncogenesis, and unknown long-term effects.

Flags

• Currently not available outside of research settings.
• Uses viral vectors (e.g., AAV) which carry risks of a significant immune response.
• Potential for insertional mutagenesis, which can increase long-term cancer risk.
• Long-term effects and safety profile in humans are completely unknown.
• Extremely high theoretical cost and inaccessible to the public.

Verdict

A highly promising but purely experimental therapy with significant unknown risks.

Created

2026-04-24T00:10:36.007539Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• systemic

Indication

Focus:

healthspan

Description:

SIRT6 is a sirtuin protein crucial for DNA repair, genomic stability, and metabolic regulation. Gene therapy aims to increase SIRT6 levels, which has been shown in animal models to extend lifespan and...

Typical Protocol

• A single administration of a viral vector (e.g., AAV) to introduce additional copies of the SIRT6 gene.