Meta Information

ID:sermorelin

Name:Sermorelin

Schema Version:1.5

Title

Sermorelin

Alternate Names

• Geref
• GHRH (1-29)

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

150

High Cost:

400

Cost Type:

monthly

Description:

Prescription cost from compounding pharmacies, often including medical consultation fees.

Summary

Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce and release its own growth hormone (GH). In a healthspan context, it aims to restore more youthful, pulsatile GH secretion patterns that decline with age (somatopause), potentially improving body composition, sleep quality, and tissue repair without the risks of direct GH administration.

Purpose

Stimulates natural growth hormone release to counter age-related decline.

Card Summary

A peptide that stimulates the pituitary gland to naturally produce and release growth hormone, aiming to restore more youthful levels for improved body composition and recovery.

Drug Class

growth-hormone-releasing-hormone-analogs

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Improves body composition and sleep but lacks direct evidence for extending human healthspan.

Evidence

Grade:

B

Score:

5.5

Justification:

Human trials show GH increase and body composition changes, but longevity-specific RCTs are lacking.

Safety

Score:

6.2

Justification:

Requires medical supervision; long-term safety for healthspan applications is not well-established.

Flags

• Requires a prescription and ongoing medical supervision.
• Long-term effects on cancer risk via IGF-1 modulation are a theoretical concern.
• Contraindicated in individuals with active malignancy.
• Prohibited for use in competitive sports by WADA.
• Glucocorticoids may blunt the growth hormone response to Sermorelin.

Verdict

A supervised option for restoring GH levels; longevity benefits are unproven.

Created

2026-04-24T00:09:54.432999Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

subcutaneous_injection

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce and release its own growth hormone (GH). In a healthspan context, it ...

Typical Protocol

• Daily subcutaneous injections of 100-300 mcg at bedtime, often cycled 5 days on/2 days off.