Meta Information

ID:semax

Name:Semax

Schema Version:1.5

Alternate Names

• N-Acetyl Semax
• N-Acetyl Semax Amidate

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

40

High Cost:

80

Cost Type:

monthly

Description:

Cost per 1-2 month supply, not covered by insurance.

Summary

Semax is a synthetic peptide fragment of the adrenocorticotropic hormone (ACTH) developed in Russia. It is primarily known for its nootropic and neuroprotective effects, believed to work by increasing brain-derived neurotrophic factor (BDNF) and modulating neurotransmitter systems. Its relevance to healthspan is speculative, focusing on the potential preservation of cognitive function and neuronal health against age-related decline, though robust evidence in this context is lacking.

Purpose

A synthetic peptide for cognitive enhancement and neuroprotection.

Drug Class

Nootropic Peptide

Drugs In Class

Empty Array

Impact

Score:

2.5

Justification:

Primarily a short-term nootropic with unproven long-term healthspan or longevity benefits.

Evidence

Grade:

D

Score:

2

Justification:

Human data exists for specific medical conditions, but lacks healthspan-focused RCTs.

Safety

Score:

6.5

Justification:

Unregulated research chemical status and lack of long-term safety data in healthy populations.

Flags

• Sourced as an unregulated research chemical in many countries, raising purity/potency concerns.
• Long-term effects on the HPA (Hypothalamic-Pituitary-Adrenal) axis are not well-studied.
• Potential for anxiety, irritability, or hair shedding in sensitive individuals.
• Lacks robust, long-term safety data for use in healthy individuals.

Verdict

Experimental nootropic with unproven relevance to core longevity pathways.

Created

2026-04-27T00:52:44.566559Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

multiple

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Semax is a synthetic peptide fragment of the adrenocorticotropic hormone (ACTH) developed in Russia. It is primarily known for its nootropic and neuroprotective effects, believed to work by increasing...

Typical Protocol

• Administer 200-600 mcg intranasally daily for 10-14 days, followed by a multi-week washout period.