Saint John's Wort is an herbal supplement primarily used to manage symptoms of mild to moderate depression. Its active compounds, such as hyperforin and hypericin, are thought to modulate neurotransmitters like serotonin, dopamine, and norepinephrine. From a healthspan perspective, its value lies in supporting mental well-being, which is a critical component of overall health, though direct evidence for extending lifespan is lacking.
Verdict
Consider for mood support, but beware of major drug interactions.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
D
MONTHLY COST
$10 - $25
Protocol
- Standard protocols target 300mg three times daily, standardized to 0.3% hypericin or 2-5% hyperforin.
Flags
- Induces CYP3A4 enzyme, reducing efficacy of many drugs (e.g., oral contraceptives, warfarin, immunosuppressants).
- High risk of serotonin syndrome when combined with SSRIs or other serotonergic drugs.
- Can cause photosensitivity, increasing the risk of sunburn, especially at higher doses.
- Product quality and standardization of active compounds can vary significantly between brands.