Meta Information

ID:saffron

Name:Saffron

Schema Version:1.5

Alternate Names

• Crocus sativus

Active Compound

Crocins, Picrocrocin, Safranal

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Supports mood, cognitive function, and provides antioxidant benefits relevant to healthy aging.

Typical Protocol

• A common protocol for mood and cognitive support is 20-30 mg of standardized saffron extract, taken once or twice daily.

Expected Cost Mean

Low Cost:

15

High Cost:

35

Cost Type:

monthly

Description:

Cost for a month's supply of saffron extract supplements, generally not covered by insurance.

Summary

Saffron, derived from the Crocus sativus flower, contains active compounds like crocins, picrocrocin, and safranal, which exhibit antioxidant, anti-inflammatory, and neuroprotective properties. These compounds are believed to modulate neurotransmitter systems, such as serotonin and dopamine, contributing to its observed benefits in mood and cognitive function. By supporting mental well-being and reducing oxidative stress, saffron indirectly contributes to overall healthspan.

Purpose

Antioxidant, anti-inflammatory, and mood enhancer; supports mental well-being.

Card Summary

Saffron, a potent antioxidant, supports mood and cognitive health, contributing to mental well-being.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:

5.2

Justification:

Supports mood, cognition, and provides antioxidant protection relevant to healthspan.

Evidence

Grade:

B

Score:

6.5

Justification:

Multiple human trials support mood and cognitive benefits, particularly for mild depression.

Safety

Score:

2.8

Justification:

Generally well-tolerated at typical doses; mild gastrointestinal side effects are uncommon.

Flags

• High doses (over 5g/day) can be toxic and should be avoided.
• May potentially interact with blood thinners (anticoagulants) or blood pressure medications.
• Pregnant or breastfeeding individuals should avoid saffron supplements due to potential uterine stimulant effects.

Verdict

Natural compound supporting mood, cognition, and antioxidant defenses.