Reishi is one of the oldest and most revered medicinal mushrooms in traditional medicine, historically known as the 'Mushroom of Immortality'. It contains a rich spectrum of polysaccharides (beta-glucans) and triterpenes. From a geroscience perspective, Reishi acts as a potent immunomodulator (balancing an overactive or underactive immune system) and exerts strong adaptogenic effects on the nervous system, helping to downregulate sympathetic tone, improve sleep quality, and reduce systemic inflammation.
Verdict
A foundational, multi-target adaptogen that tackles several systemic hallmarks of aging simultaneously.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Very Low
EVIDENCE GRADE
B
MONTHLY COST
$15 - $35
Protocol
- Take 1,000-2,000 mg of a dual-extracted fruiting body powder in the evening before bed.
Flags
- Can lower blood pressure; those with hypotension should monitor their response.
- May slow blood clotting, increasing the risk of bleeding in individuals on blood thinners.
- Must be dual-extracted (water and alcohol) to capture both the beta-glucans and the triterpenes.