Propranolol is a non-selective beta-blocker that works by blocking beta-adrenergic receptors throughout the body. This action reduces heart rate, lowers blood pressure, and decreases the heart's workload, making it effective for treating various cardiovascular conditions. It also blunts the physiological symptoms of the 'fight-or-flight' response, which is why it is used for performance anxiety.
Verdict
Highly effective, well-studied prescription drug for specific cardiovascular and anxiety conditions.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$5 - $30
Protocol
- For hypertension, dosing typically starts at 40 mg twice daily, adjusted based on response.
- For migraine prevention, the usual dose is 80-240 mg daily in divided doses.
- For performance anxiety, a single dose of 10-40 mg is taken 30-60 minutes before the event.
Flags
- Should not be stopped abruptly due to risk of rebound hypertension or cardiac events.
- Contraindicated in patients with asthma, severe bradycardia, or certain types of heart block.
- May mask symptoms of hypoglycemia in patients with diabetes.
- Common side effects include fatigue, dizziness, cold extremities, and sleep disturbances.
- Can potentially worsen symptoms of depression in susceptible individuals.