Procyanidin C1 is a plant-derived flavonoid identified as a potent senolytic, a compound that selectively induces apoptosis (cell death) in senescent cells. By clearing these dysfunctional, pro-inflammatory cells, PCC1 has been shown in animal models to improve physical function, reduce age-related disease burden, and extend lifespan. Its mechanism is thought to involve inhibiting key pro-survival pathways that senescent cells uniquely depend on.
Verdict
A highly promising preclinical senolytic, but entirely unproven in humans.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$20 - $50
Protocol
- No established human protocols exist for purified PCC1 as a senolytic agent.
- Preclinical mouse studies used intravenous doses, with oral bioavailability and efficacy being unconfirmed.
- PCC1 is a component of supplements like grape seed extract, but dosages of the specific C1 dimer are unstandardized.
Flags
- No human safety or efficacy data exists for purified PCC1 as a senolytic.
- Not commercially available as a pure compound; only as a component of extracts.
- The effective senolytic dose, frequency, and oral bioavailability in humans are unknown.
- Extracts containing PCC1 may interact with anticoagulant or antiplatelet medications.