Pregnenolone is a foundational precursor hormone from which all other steroid hormones, including DHEA, testosterone, estrogens, and cortisol, are synthesized. Supplementation is theorized to restore more youthful hormonal profiles, potentially benefiting mood, memory, and vitality. However, its metabolic pathway is highly individual and unpredictable, and direct evidence for extending healthspan in healthy individuals is currently lacking.
Verdict
A speculative prohormone requiring medical supervision and testing for targeted use.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$5 - $20
Protocol
- Typical over-the-counter doses range from 5 mg to 50 mg taken orally once daily.
- Use should be guided by baseline and follow-up blood tests for downstream hormones.
Flags
- May unpredictably alter levels of DHEA, testosterone, estrogen, and cortisol.
- Should be avoided by individuals with a history of hormone-sensitive cancers (e.g., prostate, breast).
- Potential side effects include acne, hair loss, irritability, and sleep disturbances.
- Requires regular blood testing to monitor downstream hormone levels.
- Long-term safety profile for healthspan purposes is not well established.