Meta Information
ID:phytoceramides
Name:PhytoCeramides
Schema Version:1.5
Alternate Names
- Plant-derived Ceramides
- Glycosphingolipids
Active Compound
Phytoceramides
Intervention Type
therapeutic_agent
Delivery
Route:
topical_skin
Scope:
- local
Is Skin Health
True
Regulatory Status
- us:cosmetic_ingredient
- eu:cosmetic_ingredient
Indication
Focus:
healthspan
Description:
Improving skin barrier function, hydration, and reducing the appearance of fine lines and wrinkles by replenishing lipids in the stratum corneum.
Typical Protocol
- Apply a pea-sized amount of a cream or serum containing phytoceramides to the face and neck once or twice daily, typically after cleansing.
Expected Cost Mean
Low Cost:
20
High Cost:
80
Cost Type:
monthly
Description:
Cost of over-the-counter skincare products. Not covered by insurance.
Summary
Phytoceramides are plant-derived lipids structurally identical to the ceramides naturally found in the skin's outermost layer, which deplete with age. When applied topically, they integrate into the skin's lipid barrier, reinforcing its structure to prevent transepidermal water loss (TEWL) and protect against environmental aggressors. This restoration of the barrier function leads to improved skin hydration, smoothness, and a reduction in the appearance of fine lines.
Purpose
Replenishes skin barrier lipids to improve hydration and texture.
Card Summary
Plant-derived lipids that restore the skin's natural barrier, boosting hydration and reducing wrinkles.
Drug Class
null
Drugs In Class
Empty Array
Impact
Score:
5.5
Justification:
Effectively improves skin barrier function, hydration, and reduces fine lines.
Evidence
Grade:
B
Score:
7
Justification:
Multiple human clinical studies demonstrate improved skin hydration and barrier function.
Safety
Score:
1
Justification:
Skin-identical lipid with an extremely low risk of irritation or adverse effects.
Flags
- Generally very well-tolerated, but patch testing is recommended for highly sensitive skin.
- Efficacy is highly dependent on the formulation, concentration, and inclusion of other barrier-supporting lipids like cholesterol and fatty acids.
Verdict
A safe, effective foundational ingredient for improving skin barrier and hydration.
Qualifier
route: Topical, scope: local, focused on healthspan
Created
2026-05-15T02:55:55.536723Z
Ai Model
Gemini 2.5 Pro (High)