PDE5 inhibitors work by blocking the phosphodiesterase-5 enzyme, which increases cyclic guanosine monophosphate (cGMP) levels. This leads to smooth muscle relaxation and vasodilation, improving blood flow. This mechanism is being explored for its potential benefits in cardiovascular health, endothelial function, and even neuroprotection, all key aspects of healthspan.
Verdict
A promising tool for vascular health, but requires medical supervision.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$10 - $60
Protocol
- Daily low-dose tadalafil (2.5-5 mg) is a common protocol for endothelial health.
- Sildenafil (25-50 mg) is often used as needed, but daily use is being explored.
Flags
- Must not be used with nitrate medications due to risk of severe hypotension.
- Common side effects include headache, flushing, indigestion, and nasal congestion.
- Rare but serious side effects include vision changes (NAION) and priapism.
- Requires a prescription and medical supervision.