Omega-3 fatty acids, primarily EPA and DHA, are incorporated into cell membranes throughout the body, influencing their fluidity and function. They serve as precursors to powerful anti-inflammatory signaling molecules called resolvins and protectins, which actively resolve inflammation. By competing with pro-inflammatory omega-6 fatty acids, they help shift the body towards a less inflammatory state, a key factor in mitigating age-related chronic disease.
Verdict
A high-value, safe supplement for reducing inflammation and supporting systemic health.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$15 - $50
Protocol
- For general healthspan, a typical dose is 1-2 grams of combined EPA+DHA daily.
- Prescription forms for treating high triglycerides can be up to 4 grams daily under medical supervision.
Flags
- May increase bleeding time; use with caution if taking anticoagulant or antiplatelet drugs.
- High doses can cause gastrointestinal upset or a 'fishy' aftertaste.
- Choose high-quality, third-party tested supplements to avoid contaminants like mercury and PCBs.
- Prescription forms are highly purified and regulated, unlike many dietary supplements.