Meta Information

ID:nr-liposomal

Name:Liposomal Nicotinamide Riboside

Schema Version:1.5

Alternate Names

• Liposomal NR

Active Compound

nicotinamide_riboside

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement

Indication

Focus:

healthspan

Description:

Aims to boost NAD+ levels to support cellular energy production, DNA repair, and sirtuin activity for healthy aging.

Typical Protocol

• Typical daily doses range from 250 mg to 500 mg, taken once daily.
• Often taken in the morning to align with circadian rhythms of NAD+ production.

Expected Cost Mean

Low Cost:

45

High Cost:

80

Cost Type:

monthly

Description:

Premium-priced supplement formulation; not covered by insurance.

Summary

Liposomal Nicotinamide Riboside (NR) is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme for cellular metabolism and DNA repair. The liposomal formulation encapsulates NR in lipid spheres, aiming to protect it from degradation in the digestive tract and enhance its absorption and bioavailability compared to standard NR formulations. By increasing systemic NAD+ levels, it may support mitochondrial function and activate sirtuins, proteins involved in cellular health and longevity.

Purpose

Boosts cellular NAD+ levels to support energy and repair.

Card Summary

A high-bioavailability form of Nicotinamide Riboside, a vitamin B3 precursor designed to elevate cellular NAD+ levels, supporting energy metabolism and DNA repair pathways associated with healthy aging.

Drug Class

nad_precursor

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Theoretically supports core cellular processes, but human healthspan extension data is still emerging.

Evidence

Grade:

B

Score:

6.5

Justification:

Human trials confirm NAD+ boosting, but long-term healthspan outcome data is limited.

Safety

Score:

3

Justification:

Generally well-tolerated with mild side effects; long-term data on liposomal forms is sparse.

Flags

• Liposomal formulations may significantly increase bioavailability, warranting caution with dosage compared to standard NR.
• Some preclinical studies raise concerns that high NAD+ levels could potentially fuel certain cancers, though human data is lacking.
• Common side effects include mild nausea, fatigue, headaches, or itching.

Verdict

A promising but unproven strategy for boosting cellular NAD+ via enhanced delivery.

Created

2026-06-12T17:51:22.549708Z

Ai Model

Gemini 2.5 Pro (High)