Meta Information

ID:nmn

Name:NMN

Schema Version:1.5

Alternate Names

• Nicotinamide Mononucleotide

Active Compound

nmn

Intervention Type

therapeutic_agent

Delivery

Route:

none

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:dietary_supplement

Indication

Focus:

healthspan

Description:

NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme required for cellular energy production and the activation of longevity pathway...

Expected Cost Mean

Low Cost:

30

High Cost:

120

Cost Type:

monthly

Description:

A premium-priced supplement, subject to market fluctuations and quality variations.

Summary

NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a critical coenzyme required for cellular energy production and the activation of longevity pathways, particularly sirtuins and PARPs. NAD+ levels decline significantly with age, leading to mitochondrial dysfunction and reduced cellular repair capacity. Supplementation with NMN has been shown to effectively raise systemic NAD+ levels, improving vascular health, endurance, and metabolic markers in aging animal models, with early human trials showing favorable safety and modest metabolic benefits.

Purpose

Restores declining cellular NAD+ levels to revitalize mitochondrial function and repair mechanisms.

Card Summary

A popular longevity supplement that boosts NAD+ levels to improve energy, metabolism, and cellular repair.

Drug Class

NAD+ Precursors

Drugs In Class

Empty Array

Impact

Score:

6.5

Justification:

Addresses a fundamental aging pathway (NAD+ decline), but clinical magnitude in healthy humans is still debated.

Evidence

Grade:

C

Score:

5.5

Justification:

Excellent mechanistic and animal data, but large-scale, long-term human outcome data is still emerging.

Safety

Score:

3

Justification:

Generally well-tolerated in human trials up to 1000mg daily, though long-term data is absent.

Flags

• Recent regulatory disputes with the FDA over its status as a dietary supplement vs. investigational drug.
• High prevalence of counterfeit or degraded products on the supplement market; sourcing is critical.
• Theoretical concerns about fueling existing cancers, as tumors also rely on NAD+ for rapid growth.
• May require concurrent supplementation with methyl donors (like TMG) to prevent methyl depletion.

Verdict

A promising, albeit expensive, supplement for rescuing metabolic decline associated with aging.

Typical Protocol

• Oral or sublingual dosing of 250mg to 1000mg daily, typically taken in the morning.