Niacinamide (Vitamin B3) is a precursor to NAD+ and NADP+, critical coenzymes in cellular metabolism. Topically, it enhances skin barrier function by increasing ceramide synthesis, reduces trans-epidermal water loss, and offers anti-inflammatory and antioxidant benefits. It can mitigate signs of photoaging and improve skin texture, contributing to skin healthspan.
Verdict
Effective for improving skin health, barrier, and reducing photoaging.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $50
Protocol
- Apply a serum containing 2-10% niacinamide to clean skin once or twice daily.
Flags
- Rarely, can cause temporary flushing or irritation, especially at higher concentrations.