NAD+ is a vital coenzyme essential for cellular energy production and the function of sirtuins, proteins involved in DNA repair and stress resistance. NAD+ levels decline significantly with age, and this decline is linked to many age-related dysfunctions. Intravenous administration bypasses metabolic breakdown, delivering the molecule directly to the bloodstream with the goal of restoring youthful cellular function.
Verdict
Theoretically promising but expensive and unproven for human healthspan benefits.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$500 - $1500
Protocol
- Initial loading phase of 500-1000mg infusions over several days, followed by monthly or quarterly maintenance infusions.
Flags
- Infusions can cause significant discomfort including nausea, flushing, cramping, and headache.
- Long-term effects of supra-physiological NAD+ levels in healthy humans are unknown.
- Efficacy for extending human healthspan is currently unproven in clinical trials.
- Administered in private clinics, often with variable quality control and oversight.