NAC

N-Acetylcysteine (NAC) is a supplement form of the amino acid cysteine and a direct precursor to the master antioxidant, glutathione. By replenishing intracellular glutathione levels, which naturally decline with age, NAC helps mitigate oxidative stress, a key driver of cellular aging. It also supports detoxification pathways and has mucolytic (mucus-thinning) properties.

Verdict

A safe, low-cost way to support foundational antioxidant defenses.

Protocol

• Take 600mg to 1200mg daily, often split into two doses on an empty stomach.

Flags

• May interact with nitroglycerin, potentially causing severe hypotension and headache.
• Can interact with activated charcoal and some blood pressure medications.
• High doses (>1800mg) may cause gastrointestinal distress like nausea or diarrhea.
• May blunt some positive adaptations to exercise if taken immediately post-workout.