Meta Information
ID:modafinil
Name:Modafinil
Schema Version:1.5
Alternate Names
- Provigil
- Alertec
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
30
High Cost:
100
Cost Type:
monthly
Description:
Out-of-pocket cost for generic versions; insurance rarely covers off-label use.
Summary
Modafinil is a prescription eugeroic (wakefulness-promoting agent) that increases levels of dopamine, norepinephrine, and histamine in the brain. Its relevance to healthspan is indirect and speculative, primarily through its off-label use for enhancing cognitive function, focus, and productivity. There is no direct evidence that it targets fundamental aging pathways or extends lifespan.
Purpose
A eugeroic drug used off-label for cognitive enhancement and wakefulness.
Card Summary
A prescription wakefulness agent used off-label to enhance cognitive function and combat fatigue, with no direct evidence for longevity benefits.
Drug Class
eugeroic
Drugs In Class
Empty Array
Impact
Score:
2.5
Justification:
Indirect benefits via cognitive enhancement; no direct evidence for lifespan extension.
Evidence
Grade:
D
Score:
1
Justification:
No human trials exist for modafinil's direct impact on healthspan or longevity.
Safety
Score:
7.2
Justification:
Prescription drug with risks of dependency, cardiac issues, and severe skin reactions.
Flags
- Risk of severe, life-threatening skin rashes like Stevens-Johnson Syndrome (SJS).
- May increase heart rate and blood pressure; caution advised for cardiovascular conditions.
- Has potential for psychological dependence and abuse.
- Can interact with and reduce the effectiveness of hormonal contraceptives.
- Common side effects include anxiety, insomnia, headache, and nausea.
- Long-term effects of chronic use on brain health are not well-studied.
Verdict
A high-risk cognitive tool, not a core healthspan intervention.
Created
2026-04-27T00:41:18.157197Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Modafinil is a prescription eugeroic (wakefulness-promoting agent) that increases levels of dopamine, norepinephrine, and histamine in the brain. Its relevance to healthspan is indirect and speculativ...
Typical Protocol
- Take 50-200 mg in the morning as needed for cognitive focus or to combat fatigue.
- Consider cycling (e.g., 2-3 times per week) to mitigate tolerance and dependence.
- Always use under the guidance of a qualified medical professional.