Meta Information

ID:meclizine

Name:Meclizine

Schema Version:1.5

Alternate Names

• Antivert
• Bonine
• Dramamine Less Drowsy

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

15

Cost Type:

monthly

Description:

Very inexpensive generic over-the-counter medication.

Summary

Meclizine is an over-the-counter antihistamine primarily used for motion sickness and vertigo. Its relevance to longevity stems from its function as a weak mTOR inhibitor, a key pathway in aging. In the NIA's Interventions Testing Program (ITP), meclizine demonstrated a modest lifespan extension in male mice, but notably, not in females.

Purpose

Weak mTOR inhibitor investigated for pro-longevity effects.

Card Summary

An over-the-counter antihistamine that weakly inhibits mTOR, showing lifespan extension in male mice but with significant long-term safety concerns.

Drug Class

h1-antihistamine

Drugs In Class

Empty Array

Impact

Score:

3

Justification:

Modest lifespan extension in male mice only; no human longevity data.

Evidence

Grade:

C

Score:

3.5

Justification:

High-quality animal data (ITP) but lacks any human longevity trials.

Safety

Score:

5.5

Justification:

Anticholinergic effects are linked to long-term cognitive decline and dementia risk.

Flags

• Long-term use of anticholinergic drugs is associated with an increased risk of dementia.
• Common side effect is drowsiness; avoid operating heavy machinery.
• May interact with CNS depressants like alcohol, sedatives, and tranquilizers.
• Lifespan extension was only observed in male mice in the ITP study, not females.

Verdict

Promising mouse data is overshadowed by significant long-term cognitive safety concerns.

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Meclizine is an over-the-counter antihistamine primarily used for motion sickness and vertigo. Its relevance to longevity stems from its function as a weak mTOR inhibitor, a key pathway in aging. In t...

Typical Protocol

• A speculative protocol involves taking 12.5mg to 25mg once or twice weekly, based on animal study conversions.

Non Healthspan

True