Meta Information

ID:mdma-therapy

Name:MDMA Therapy

Schema Version:1.5

Title

MDMA Therapy

Alternate Names

• 3,4-Methylenedioxymethamphetamine-Assisted Therapy
• MDMA-Assisted Psychotherapy

Intervention Type

procedure

Expected Cost Mean

Low Cost:

10000

High Cost:

15000

Cost Type:

one time

Description:

Full course of treatment including drug, therapy sessions, and medical supervision.

Summary

MDMA-assisted therapy facilitates profound psychological breakthroughs by reducing fear and defensiveness while increasing empathy and introspection. From a healthspan perspective, its primary value lies in resolving severe psychological trauma (e.g., PTSD), which is a significant driver of chronic stress, inflammation, and accelerated biological aging. By addressing the root psychological drivers of allostatic load, it may indirectly improve long-term physiological resilience and reduce the burden of stress-related disease.

Purpose

Resolves psychological trauma to reduce chronic stress and inflammation.

Card Summary

A therapeutic protocol using MDMA to resolve psychological trauma, a key driver of chronic stress and accelerated aging.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Potentially high leverage for resolving trauma, a major driver of allostatic load.

Evidence

Grade:

B

Score:

7.5

Justification:

Multiple Phase 3 human RCTs show high efficacy for PTSD treatment.

Safety

Score:

7.8

Justification:

Schedule I drug with cardiovascular risks; requires strict medical supervision.

Flags

• Currently a Schedule I controlled substance in the US, only legally available in clinical trials or via expanded access.
• Significant risk of serotonin syndrome when combined with SSRIs, SNRIs, or MAOIs.
• Poses acute cardiovascular risks (hypertension, tachycardia); contraindicated for individuals with heart conditions.
• Potential for neurotoxicity with frequent or high-dose recreational use, distinct from clinical protocols.
• Must be conducted in a controlled, therapeutic setting with trained professionals.

Verdict

A powerful, high-risk tool for resolving trauma-driven accelerated aging.

Created

2026-04-23T23:43:12.525859Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• systemic

Indication

Focus:

healthspan

Description:

MDMA-assisted therapy facilitates profound psychological breakthroughs by reducing fear and defensiveness while increasing empathy and introspection. From a healthspan perspective, its primary value l...

Typical Protocol

• A full therapeutic course typically involves 2-3 sessions, each with a single 80-120mg dose.
• Administered under strict medical supervision with integrated psychotherapy before, during, and after dosing.