Meta Information

ID:lutein

Name:Lutein

Schema Version:1.5

Alternate Names

• Zeaxanthin

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

25

Cost Type:

monthly

Description:

Widely available over-the-counter supplement for eye health; not covered by insurance.

Summary

Lutein is a carotenoid antioxidant that concentrates in the macula of the eye, filtering harmful blue light and neutralizing oxidative stress. Its primary healthspan relevance is in preserving vision by reducing the risk and progression of age-related macular degeneration (AMD) and cataracts. Emerging evidence also suggests a role in supporting cognitive function with age.

Purpose

A carotenoid antioxidant protecting vision and potentially cognitive function.

Card Summary

A key carotenoid antioxidant that accumulates in the eye to protect against age-related vision loss and may support cognitive health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Highly effective for a specific, high-value goal: preserving long-term vision.

Evidence

Grade:

A

Score:

9

Justification:

Supported by large-scale, long-term human RCTs like the AREDS2 study for AMD.

Safety

Score:

1.5

Justification:

Generally Recognized As Safe (GRAS) dietary carotenoid with an excellent safety profile.

Flags

• Often formulated with zeaxanthin, as they work synergistically in the macula.
• Absorption is significantly enhanced when taken with a meal containing dietary fat.
• Smokers should consult a physician before taking high-dose carotenoid supplements.

Verdict

A well-evidenced, safe supplement for preserving long-term vision.

Created

2026-04-26T17:37:46.893338Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Lutein is a carotenoid antioxidant that concentrates in the macula of the eye, filtering harmful blue light and neutralizing oxidative stress. Its primary healthspan relevance is in preserving vision ...

Typical Protocol

• Daily supplementation of 10-20 mg of lutein, often combined with 2-4 mg of zeaxanthin.