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Low-Dose Colchicine

Colcrys, Mitigare, Gloperba

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Meta Information

ID:low-dose-colchicine
Name:Low-Dose Colchicine
Schema Version:1.5

Alternate Names

  • Colcrys
  • Mitigare
  • Gloperba

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
60
Cost Type:
monthly
Description:
Generic prescription cost; often covered by insurance for approved indications.

Summary

Colchicine is a potent anti-inflammatory drug that inhibits the NLRP3 inflammasome, a key pathway in age-related chronic inflammation ('inflammaging'). By reducing this low-grade inflammation, it has been shown in large clinical trials to significantly lower the risk of major adverse cardiovascular events like heart attacks and strokes.

Purpose

Reduces systemic inflammation to lower cardiovascular disease risk.

Card Summary

A potent anti-inflammatory drug that targets the NLRP3 inflammasome to reduce chronic inflammation and lower cardiovascular event risk.

Drug Class

microtubule-inhibitor

Drugs In Class

Empty Array

Impact

Score:
7.2
Justification:
Strong RCT evidence for reducing major adverse cardiovascular events (MACE).

Evidence

Grade:
A
Score:
9
Justification:
Multiple large-scale human RCTs (LoDoCo2, COLCOT) confirm cardiovascular benefits.

Safety

Score:
5.5
Justification:
Narrow therapeutic index; common GI side effects and significant drug interactions.

Flags

  • Requires a prescription and medical supervision.
  • Common side effects include diarrhea, nausea, and abdominal cramping.
  • Increased risk of muscle pain or damage (myopathy) when taken with statins.
  • Interacts with many common drugs, including certain antibiotics and antifungals (CYP3A4 inhibitors).
  • Overdose is extremely toxic and can be fatal.
  • Contraindicated in patients with severe kidney or liver disease.

Verdict

A proven tool for reducing cardiovascular risk via inflammation modulation.

Created

2026-04-27T00:55:51.379434Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
disease_treatment
Description:
Colchicine is a potent anti-inflammatory drug that inhibits the NLRP3 inflammasome, a key pathway in age-related chronic inflammation ('inflammaging'). By reducing this low-grade inflammation, it has ...

Typical Protocol

  • A typical protocol involves taking a 0.5 mg tablet once daily.