Meta Information

ID:l-tyrosine

Name:L-Tyrosine

Schema Version:1.5

Alternate Names

• Tyrosine

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

20

Cost Type:

monthly

Description:

Widely available over-the-counter amino acid supplement.

Summary

L-Tyrosine is a non-essential amino acid that acts as a precursor to catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Its primary relevance to healthspan is not direct lifespan extension but rather supporting cognitive resilience during acute stress. By replenishing neurotransmitters depleted by stress, it may help mitigate the long-term neurological wear-and-tear associated with chronic stress responses.

Purpose

Amino acid precursor for dopamine to support cognition under stress.

Card Summary

An amino acid that supports cognitive function under stress by replenishing key neurotransmitters like dopamine and norepinephrine.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.8

Justification:

Supports acute cognitive function under stress; no direct evidence for lifespan extension.

Evidence

Grade:

B

Score:

6.5

Justification:

Human RCTs confirm cognitive benefits under stress; direct longevity link is theoretical.

Safety

Score:

2.5

Justification:

Generally Recognized As Safe (GRAS) amino acid with a strong safety profile.

Flags

• Avoid if taking MAOI antidepressants due to risk of hypertensive crisis.
• May interact with thyroid hormone medication; consult a physician if you have a thyroid condition.
• Can interfere with levodopa (L-DOPA) medication used for Parkinson's disease.
• High doses (>150mg/kg bodyweight) may cause nausea, headache, or fatigue.

Verdict

A useful tool for cognitive support during acute stress, not foundational.

Created

2026-04-27T00:49:15.966760Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

L-Tyrosine is a non-essential amino acid that acts as a precursor to catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Its primary relevance to healthspan is not di...

Typical Protocol

• Take 500-2000 mg 30-60 minutes before acute stressors to support cognitive function.