L-Ergothioneine is a unique antioxidant amino acid that humans cannot synthesize and must obtain from diet, primarily mushrooms. It accumulates in cells via a specific transporter (ETT/OCTN1), protecting mitochondria and DNA from oxidative damage. Its potential role as a 'longevity vitamin' is based on its ability to counteract cellular stress, a key driver of aging.
Verdict
A safe, promising antioxidant, but its healthspan benefits remain largely unproven.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$20 - $50
Protocol
- Typical daily doses in supplements range from 5 mg to 30 mg.
Flags
- No significant adverse effects or drug interactions have been reported at typical doses.