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KPV (Topical)

Lys-Pro-Val, Alpha-Melanocyte Stimulating Hormone Fragment

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Meta Information

ID:kpv
Name:KPV
Schema Version:1.5

Alternate Names

  • Lys-Pro-Val
  • Alpha-Melanocyte Stimulating Hormone Fragment

Active Compound

KPV

Intervention Type

therapeutic_agent

Delivery

Route:
topical_skin
Scope:
  • systemic
  • local

Is Skin Health

False

Regulatory Status

  • us:research_chemical
  • eu:research_chemical
  • us:cosmetic_ingredient

Indication

Focus:
symptom_management
Description:
Manages inflammation, supports wound healing, and modulates immune responses.

Typical Protocol

  • Topical application in creams or gels 1-2 times daily for localized inflammatory conditions.
  • Subcutaneous injection protocols are highly variable and primarily used in research settings.

Expected Cost Mean

Low Cost:
30
High Cost:
100
Cost Type:
monthly
Description:
Cost for research peptide vial; typically not covered by insurance.

Summary

KPV is a tripeptide (Lys-Pro-Val) derived from alpha-Melanocyte Stimulating Hormone (alpha-MSH). It exhibits potent anti-inflammatory, antimicrobial, and immunomodulatory properties, primarily by inhibiting NF-κB activation pathways. While its role in directly extending healthspan is not well-established, these actions could theoretically mitigate chronic inflammation, a known driver of aging and various age-related pathologies.

Purpose

Anti-inflammatory, antimicrobial peptide; may mitigate age-related chronic inflammation.

Card Summary

KPV is an anti-inflammatory peptide; research explores its role in inflammation and immunity.

Drug Class

null

Drugs In Class

Empty Array

Impact

Score:
2.5
Justification:
Emerging experimental data for inflammation, limited direct healthspan evidence.

Evidence

Grade:
C
Score:
3
Justification:
Primarily animal and in-vitro studies; human data for healthspan is scarce.

Safety

Score:
6.5
Justification:
Limited long-term human safety data; considered a research chemical.

Flags

  • Regulatory status as a research chemical means quality and purity are not guaranteed.
  • Long-term systemic safety profile in humans for healthspan applications is largely unknown.
  • Potential for immune modulation, requiring careful consideration in individuals with autoimmune conditions.

Verdict

Experimental peptide, anti-inflammatory; healthspan relevance speculative, safety data limited.