Meta Information

ID:klotho

Name:Klotho

Schema Version:1.5

Title

Klotho

Alternate Names

• alpha-Klotho
• α-Klotho

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10000

High Cost:

50000

Cost Type:

one time

Description:

Estimated cost for future gene therapy or recombinant protein course; not commercially available.

Summary

Klotho is a circulating hormone and transmembrane protein that declines significantly with age. Higher endogenous levels are strongly associated with increased lifespan in animals and improved cognition in humans, and it functions by modulating insulin/IGF-1 signaling, reducing oxidative stress, and regulating mineral metabolism.

Purpose

A master-regulatory protein that may reverse age-related cognitive decline.

Card Summary

A circulating hormone that declines with age; restoring it may reverse age-related cognitive decline and improve overall healthspan.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.8

Justification:

Potentially systemic anti-aging effects, especially on cognition, but human data is very limited.

Evidence

Grade:

C

Score:

3.9

Justification:

Strong animal and human observational data, but lacks human longevity intervention trials.

Safety

Score:

7.5

Justification:

Experimental biologic with limited human safety data and potential for unknown long-term effects.

Flags

• Not commercially available; currently in clinical trials for specific disease indications.
• Potential for disrupting calcium and phosphate homeostasis due to its interaction with FGF23.
• Long-term effects of supraphysiological Klotho levels in humans are unknown.
• Different forms (soluble, membrane-bound) have different functions, complicating therapeutic development.

Verdict

A top-tier future therapy; currently unavailable outside of clinical trials.

Created

2026-04-23T23:40:02.310983Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

subcutaneous_injection

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Klotho is a circulating hormone and transmembrane protein that declines significantly with age. Higher endogenous levels are strongly associated with increased lifespan in animals and improved cogniti...

Typical Protocol

• Currently in clinical trials; no established human healthspan protocol exists.
• Protocols aim to restore circulating Klotho levels to those of a healthy young adult.