Meta Information

ID:ketogenic-diet

Name:Ketogenic Diet

Schema Version:1.5

Title

Ketogenic Diet

Alternate Names

• Keto
• Keto Diet

Intervention Type

dietary_practice

Expected Cost Mean

Low Cost:

0

High Cost:

300

Cost Type:

monthly

Description:

Cost varies based on food quality and reliance on specialty keto products.

Summary

The ketogenic diet shifts the body's primary fuel source from glucose to ketones by severely restricting carbohydrates. This metabolic state may promote longevity by activating pathways like AMPK, reducing inflammation, improving insulin sensitivity, and enhancing mitochondrial function, thereby mimicking some of the beneficial effects of fasting.

Purpose

Shifts metabolism to ketones to improve insulin sensitivity and cellular signaling.

Card Summary

A very low-carb, high-fat diet that shifts metabolism to ketones, potentially improving insulin sensitivity and activating longevity pathways.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.5

Justification:

Potent metabolic shift with broad effects on insulin sensitivity, inflammation, and cellular signaling.

Evidence

Grade:

B

Score:

6.8

Justification:

Strong human data for metabolic benefits; direct longevity evidence is largely preclinical or inferred.

Safety

Score:

2.5

Justification:

Generally safe but restrictive; requires planning to avoid nutrient deficiencies and manage side effects.

Flags

• Initial adaptation period may cause 'keto flu' symptoms like fatigue and headache.
• Long-term adherence can be challenging due to social and dietary restrictions.
• May significantly alter lipid profiles (e.g., LDL-C); monitoring is recommended.
• Risk of micronutrient deficiencies if not well-formulated.
• Use with SGLT2 inhibitors increases risk of euglycemic ketoacidosis.

Verdict

A powerful metabolic tool for specific goals, but long-term adherence is key.

Created

2026-04-23T23:39:44.342985Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• systemic

Indication

Focus:

healthspan

Description:

The ketogenic diet shifts the body's primary fuel source from glucose to ketones by severely restricting carbohydrates. This metabolic state may promote longevity by activating pathways like AMPK, red...

Typical Protocol

• Maintain a macronutrient ratio of approximately 70-80% fat, 15-25% protein, and 5-10% carbohydrates.
• Utilize blood ketone monitoring to confirm nutritional ketosis, typically aiming for 0.5-3.0 mmol/L.
• Consider cycling in and out of ketosis to promote long-term metabolic flexibility.