Meta Information
ID:iron-gluconate
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:37:15.275350Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to bisphosphonates, significantly reducing the absorption and effectiveness of both medications.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/levothyroxine
Target name:
Levothyroxine
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to levothyroxine in the gut, which can significantly decrease its absorption and thyroid hormone effectiveness.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/levodopa
Target name:
Levodopa
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron can bind with levodopa in the gut, reducing its absorption and effectiveness for Parkinson's symptoms.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These medications can bind to iron in the gut, preventing its absorption and reducing its effectiveness.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These drugs reduce stomach acid, which is necessary for optimal absorption of iron from supplements.
Actionable advice:
Discuss timing with your doctor.
Target id:
/intervention/famotidine
Target name:
Famotidine
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
This drug reduces stomach acid, which is necessary for optimal absorption of iron from supplements.
Actionable advice:
Discuss timing with your doctor.
Target id:
/intervention/green-tea-extract
Target name:
Green Tea Extract
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Polyphenols (tannins) in green tea extract strongly bind to iron, inhibiting its absorption from the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/calcium-citrate
Target name:
Calcium Citrate
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Calcium competes with iron for absorption in the gut, reducing the amount of iron the body receives.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Magnesium competes with iron for absorption in the gut, potentially reducing the amount of iron absorbed.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/polyphenol-rich-foods
Target name:
Polyphenol-rich Foods
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Polyphenols in foods like tea, coffee, and red wine bind to iron, inhibiting its absorption.
Actionable advice:
Separate doses from these foods.
Target id:
/intervention/vitamin-c
Target name:
Vitamin C
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin C significantly enhances the absorption of non-heme iron by converting it to a more usable form.
Actionable advice:
Take together with iron.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of zinc can compete with iron for absorption pathways in the gut, reducing effectiveness.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/copper
Target name:
Copper
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of copper can compete with iron for the same absorption pathway in the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/phytoestrogens-soy-isoflavones
Target name:
Phytoestrogens: Soy Isoflavones
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Compounds in soy products can bind to iron in the gut, significantly reducing its absorption.
Actionable advice:
Separate doses from soy intake.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Compounds like tannins found in caffeinated drinks (coffee, tea) can significantly reduce iron absorption.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/high-fiber-diet
Target name:
High-Fiber Diet
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Phytates in high-fiber foods like whole grains and legumes can bind to iron and reduce its absorption.
Actionable advice:
Take iron between meals.