Meta Information
ID:iron-fumarate
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:38:02.719258Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to these antibiotics, preventing absorption of both and reducing antibiotic effectiveness.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Forms a complex with iron, significantly reducing the absorption of both the drug and iron.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/class/thyroid-hormones
Target name:
Thyroid Hormones
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron binds to thyroid medication in the gut, significantly reducing its absorption and effectiveness.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/class/antacids
Target name:
Multivalent Cation Antacids
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Reduces stomach acid and contains minerals that bind to iron, severely impairing its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/levodopa
Target name:
Levodopa
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Iron can bind to levodopa in the gut, reducing its absorption and clinical effectiveness.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/calcium-citrate
Target name:
Calcium Citrate
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Calcium competes directly with iron for absorption, significantly reducing the amount your body takes in.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Strongly reduces stomach acid required for iron absorption, impairing its uptake from supplements.
Actionable advice:
Monitor iron levels with long-term use.
Target id:
/intervention/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These medications can bind to iron in the gut, preventing its proper absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/green-tea-extract
Target name:
Green Tea Extract
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
High levels of tannins in green tea strongly bind to iron, inhibiting its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Quercetin is a potent iron chelator that binds to iron, preventing its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/vitamin-c
Target name:
Vitamin C
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Significantly enhances the absorption of iron by converting it to a more easily absorbed form.
Actionable advice:
Take together for best results.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Zinc and iron compete for the same absorption pathways; high doses inhibit each other.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/dietary/calcium-rich-foods
Target name:
Dairy and Calcium-Fortified Foods
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Calcium in dairy and fortified foods competes with and inhibits the absorption of iron.
Actionable advice:
Separate from iron dose by 2+ hours.
Target id:
/dietary/phytate-rich-foods
Target name:
Phytate-Rich Foods (Grains, Legumes, Nuts)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Phytates in whole grains and legumes are potent inhibitors of iron absorption from meals.
Actionable advice:
Separate from high-phytate meals.
Target id:
/dietary/vitamin-c-rich-foods
Target name:
Vitamin C-Rich Foods (Citrus, Bell Peppers)
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin C greatly enhances the body's ability to absorb iron from plant-based foods.
Actionable advice:
Consume with iron-rich meals.
Target id:
/class/h2-receptor-antagonists
Target name:
H2 Receptor Antagonists (H2 Blockers)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Reduces stomach acid needed for optimal iron absorption, potentially lowering its effectiveness over time.
Actionable advice:
Monitor iron levels with long-term use.
Target id:
/intervention/multivitamin-men
Target name:
Multivitamin (Men)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Often contains minerals like calcium and zinc that compete with iron for absorption.
Actionable advice:
Separate from high-dose iron if needed.
Target id:
/intervention/multivitamin-women
Target name:
Multivitamin (Women)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Often contains minerals like calcium and zinc that compete with iron for absorption.
Actionable advice:
Separate from high-dose iron if needed.
Target id:
/intervention/alpha-lipoic-acid
Target name:
Alpha-Lipoic Acid
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Can bind to iron in the gut, reducing its absorption and overall effectiveness.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/curcumin
Target name:
Curcumin
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Curcumin is a natural iron chelator that can bind to iron and reduce its absorption.
Actionable advice:
Separate doses by at least 4 hours.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of magnesium can compete with iron for absorption in the small intestine.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/dietary/caffeinated-beverages
Target name:
Caffeinated Beverages (Coffee, Tea)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Tannins in coffee and tea bind to iron, significantly reducing its absorption from the gut.
Actionable advice:
Separate from iron dose by 2+ hours.
Target id:
/dietary/soy-products
Target name:
Soy Products (Milk, Protein, Isoflavones)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Soy protein contains compounds that can significantly inhibit the absorption of dietary iron.
Actionable advice:
Separate from iron dose by 2+ hours.
Target id:
/intervention/psyllium-husk
Target name:
Psyllium Husk
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High fiber content can bind to iron and decrease its absorption in the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/copper
Target name:
Copper
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of copper can compete with iron for absorption pathways in the gut.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/dietary/high-fiber-meal
Target name:
High-Fiber Meal
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Dietary fiber can bind to iron, slightly reducing the total amount absorbed from a meal.
Actionable advice:
Take iron between high-fiber meals.
Target id:
/dietary/oxalate-rich-foods
Target name:
Oxalate-Rich Foods (Spinach, Rhubarb, Beets)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Oxalates found in foods like spinach can bind to iron and inhibit its absorption.
Actionable advice:
Separate from high-oxalate meals.
Target id:
/intervention/milk-thistle
Target name:
Milk Thistle (Silymarin)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
The active compound, silymarin, may bind to iron and slightly reduce its absorption.
Actionable advice:
Separate doses by a few hours.
Target id:
/intervention/panax-ginseng
Target name:
Panax Ginseng
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Some components in ginseng may theoretically bind to iron and slightly reduce its absorption.
Actionable advice:
Separate doses by 2 hours.