Hyperbaric Oxygen Therapy involves breathing 100% oxygen in a pressurized chamber, which dramatically increases the oxygen dissolved in blood plasma. This state of hyperoxia is proposed to trigger regenerative pathways, including mobilizing stem cells, promoting new blood vessel growth (angiogenesis), reducing inflammation, and clearing senescent cells. Recent human trials suggest it may also lengthen telomeres, a key biomarker of cellular aging.
Verdict
Promising for cellular rejuvenation, but costly with a significant time commitment.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$15000 - $30000
Protocol
- A common healthspan protocol involves 60 daily sessions of 90 minutes at 2.0 atmospheres absolute (ATA) with intermittent air breaks.
Flags
- Risk of barotrauma to ears, sinuses, and lungs is the most common side effect.
- Can cause temporary nearsightedness (myopia) that typically resolves after treatment ends.
- Contraindicated for individuals with an untreated pneumothorax (collapsed lung).
- Rare risk of central nervous system oxygen toxicity (seizures) at higher pressures.
- May accelerate the maturation of pre-existing cataracts.