← Back to Directory

Huperzine A

HupA, Qian Ceng Ta

Visual ViewRaw DataInteraction Data

Meta Information

ID:huperzine-a
Name:Huperzine A
Schema Version:1.5

Alternate Names

  • HupA
  • Qian Ceng Ta

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
5
High Cost:
20
Cost Type:
monthly
Description:
Widely available over-the-counter supplement; not covered by insurance.

Summary

Huperzine A is a naturally derived acetylcholinesterase inhibitor, meaning it increases the level of the neurotransmitter acetylcholine in the brain. This mechanism is primarily associated with improving memory, learning, and cognitive function. Its relevance to healthspan is focused on neuroprotection and potentially mitigating age-related cognitive decline, a critical component of maintaining quality of life.

Purpose

A cognitive enhancer that may protect against age-related cognitive decline.

Card Summary

An acetylcholinesterase inhibitor used to support memory and cognitive function.

Drug Class

acetylcholinesterase-inhibitor

Drugs In Class

Empty Array

Impact

Score:
3.5
Justification:
Primarily targets cognitive function with limited evidence for systemic healthspan extension.

Evidence

Grade:
B
Score:
6
Justification:
Human RCTs exist, but primarily for Alzheimer's, not healthy aging or longevity.

Safety

Score:
3.8
Justification:
Generally well-tolerated at standard doses but has cholinergic side effects and drug interactions.

Flags

  • Interacts with anticholinergic drugs, beta-blockers, and other acetylcholinesterase inhibitors.
  • Can cause cholinergic side effects like nausea, sweating, and blurred vision.
  • Not recommended for individuals with bradycardia, epilepsy, or peptic ulcers.
  • Long-term safety data in healthy individuals is limited.

Verdict

A targeted nootropic for cognitive support, not a core longevity agent.

Created

2026-04-27T00:55:05.934348Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
disease_treatment
Description:
Huperzine A is a naturally derived acetylcholinesterase inhibitor, meaning it increases the level of the neurotransmitter acetylcholine in the brain. This mechanism is primarily associated with improv...

Typical Protocol

  • Take 50-200 mcg once or twice daily, often cycled (e.g., 2-4 weeks on, 1 week off) to prevent tolerance.