Meta Information
ID:holy-basil
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulant and Antiplatelet Drugs
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Holy Basil may have antiplatelet properties, potentially slowing blood clotting. Combining it with medications like warfarin, clopidogrel, or aspirin could increase the risk of bruising and bleeding.
Actionable advice:
Consult your healthcare provider before combining with any blood-thinning medications.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Holy Basil can lower blood sugar levels. Taking it alongside diabetes medications (e.g., metformin, insulin, sulfonylureas) may cause an additive effect, increasing the risk of hypoglycemia (abnormally low blood sugar).
Actionable advice:
Monitor blood glucose levels closely if combining with diabetes medications and consult your doctor.
Target id:
/procedure/surgery
Target name:
Scheduled Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its potential effects on blood clotting and blood sugar, Holy Basil may increase bleeding risk and interfere with glucose control during and after surgical procedures.
Actionable advice:
Discontinue use at least 2 weeks prior to any scheduled surgery.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Traditionally and in animal studies, Holy Basil has been shown to have anti-fertility effects and may stimulate uterine contractions. Its safety during pregnancy has not been established.
Actionable advice:
Avoid completely if you are pregnant or trying to conceive.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient reliable information about the safety of taking Holy Basil when breast-feeding. Due to potential hormonal effects, it is best to avoid use.
Actionable advice:
Avoid use while breastfeeding due to a lack of safety data.
Target id:
/class/cns-depressants
Target name:
CNS Depressants (Sedatives)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Holy Basil possesses calming and mild sedative properties. Combining it with other central nervous system depressants, such as benzodiazepines or barbiturates, could lead to excessive drowsiness and sedation.
Actionable advice:
Use caution when combining with sedative medications and avoid activities requiring mental alertness.
Target id:
/intervention/alcohol
Target name:
Alcohol
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The mild sedative effects of Holy Basil can be amplified by alcohol consumption, potentially leading to increased drowsiness and impairment.
Actionable advice:
Avoid or limit alcohol consumption when taking Holy Basil, especially if you need to be alert.
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining Holy Basil with other supplements that affect blood clotting (e.g., ginkgo, garlic, ginger, fish oil) could theoretically increase the risk of bleeding or bruising.
Actionable advice:
Exercise caution when combining with other supplements known to thin the blood.
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Taking Holy Basil with other supplements that lower blood sugar, such as berberine, alpha-lipoic acid, or chromium, may have an additive effect and increase the risk of hypoglycemia.
Actionable advice:
Monitor for symptoms of low blood sugar if combining with other glucose-lowering supplements.
Target id:
/class/cyp1a2-substrates
Target name:
CYP1A2 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
In vitro evidence suggests Holy Basil may inhibit the CYP1A2 enzyme, which could theoretically increase levels and effects of drugs metabolized by this pathway, such as caffeine or theophylline.
Actionable advice:
Be mindful of potential increased effects of CYP1A2-metabolized drugs, though clinical significance is low.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Holy Basil components may inhibit the CYP2C9 enzyme, potentially increasing concentrations of medications like certain NSAIDs (e.g., ibuprofen) or warfarin, although this is largely theoretical.
Actionable advice:
Use with caution if taking medications primarily metabolized by CYP2C9; consult a pharmacist.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is a theoretical risk that Holy Basil could inhibit the CYP3A4 enzyme, which is responsible for metabolizing many common medications. This could potentially increase drug levels and side effects.
Actionable advice:
While the clinical risk is likely low, be aware of this potential interaction with CYP3A4-metabolized drugs.
Target id:
/condition/thyroid-disorders
Target name:
Thyroid Disorders
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some animal studies suggest that very high doses of Holy Basil may lower levels of thyroxine (T4). The effect in humans is unclear, but caution is warranted for those with hypothyroidism.
Actionable advice:
If you have a thyroid condition, especially hypothyroidism, use Holy Basil with caution and monitor your symptoms.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Holy Basil contains eugenol, which in very high doses can be hepatotoxic. Individuals with pre-existing liver conditions may be more susceptible to adverse effects.
Actionable advice:
Consult a healthcare provider before use if you have any form of liver disease.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking Holy Basil with food can help minimize the potential for mild gastrointestinal upset, improving overall tolerability.
Actionable advice:
Take with a meal to reduce the chance of stomach discomfort.