Meta Information

ID:hmb

Name:HMB

Schema Version:1.5

Alternate Names

• Beta-Hydroxy Beta-Methylbutyrate

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

15

High Cost:

35

Cost Type:

monthly

Description:

Cost for a typical 30-day supply of HMB powder or capsules.

Summary

HMB is a metabolite of the essential amino acid leucine. Its primary proposed mechanism involves simultaneously stimulating muscle protein synthesis via the mTOR pathway and inhibiting muscle protein breakdown (proteolysis). For healthspan, its relevance is focused on combating sarcopenia (age-related muscle loss), a key driver of frailty, metabolic decline, and reduced functional independence in older adults.

Purpose

A leucine metabolite that may reduce muscle breakdown.

Card Summary

A metabolite of the amino acid leucine, HMB is studied for its potential to reduce age-related muscle loss (sarcopenia) by inhibiting protein breakdown and supporting muscle synthesis.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Targeted benefit for mitigating sarcopenia, a key component of frailty.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple human RCTs and meta-analyses exist, primarily in elderly and clinical populations.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with a strong safety profile in human trials.

Flags

• Evidence for benefit is strongest in untrained, elderly, or clinical populations.
• May be less effective for individuals already consuming high-protein diets and resistance training.

Verdict

A safe, targeted supplement for potentially mitigating age-related muscle loss.

Created

2026-04-27T00:51:28.782028Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

multiple

Scope:

• systemic

Indication

Focus:

healthspan

Description:

HMB is a metabolite of the essential amino acid leucine. Its primary proposed mechanism involves simultaneously stimulating muscle protein synthesis via the mTOR pathway and inhibiting muscle protein ...

Typical Protocol

• Take 3 grams daily, often split into three 1-gram doses with meals.